Mercedes Benz has traditionally introduced its safety innovations in the S-Class. For instance, the S-Class was the first car in Europe to incorporate airbags. S-Class safety features include the following innovations in active safety (accident avoidance), passive safety (collision protection), and holistic safety (integration of both active and passive safety features):

* Active safety: ABS braking in 1978 (acts to reduce braking distances and improve stopping control; co-developed with Bosche); traction control and Electronic Stability Program (ESP) in 1995 (improves driver control during difficult road conditions); and Brake Assist (provides full braking power during emergency stops). In 2005, a new infrared night vision feature was introduced (improves visibility during nighttime conditions).

* Passive safety: crumple zones in 1957 (vehicle body structure absorbs the force of impact); three-point seatbelts in 1965 (provides additional torso/body protection); collapsible steering column (prevents the steering column from protruding into the cabin during accidents), strengthened occupant cell enhanced occupant protection during severe impacts, rollovers); pre-accident seatbelt tensioning (tightens seatbelts prior to impact), and sandwich platforms (allows the engine the slide under the occupants in a head-on collision).

* PRE-SAFE, Mercedes-Benz’s holistic safety feature, was introduced on the S-Class in 2002. PRE-SAFE integrates multiple active and passive safety features for a “safety net” approach to vehicle safety by attempting to prevent accidents; if accidents do occur, PRE-SAFE aims to reduce occupant injury. In the latest version of this pre-collision system, PRE-SAFE will prime the brake assist system, and adjust the seats, close windows, and tighten seatbelts during certain types of collisions.

Road accident statistics on a model-by-model basis from the UK Department of Transport show that the Mercedes-Benz S-Class is one of the safest cars on the UK roads (measured in terms of chance of death in an accident).